Synthesis of the thapsigargins

  • Ley S
  • Antonello A
  • Balskus E
 et al. 
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Abstract

The thapsigargins are a family of complex guaianolides with potent and selective Ca(2+)-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.

Author-supplied keywords

  • Apiaceae
  • Apiaceae: chemistry
  • Biological Products
  • Biological Products: chemical synthesis
  • Biological Products: chemistry
  • Chemistry, Organic
  • Chemistry, Organic: methods
  • Molecular Structure
  • Organic
  • Organic: methods
  • Stereoisomerism
  • Thapsigargin
  • Thapsigargin: analogs & derivatives
  • Thapsigargin: chemical synthesis
  • Thapsigargin: chemistry

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Authors

  • Steven V Ley

  • Alessandra Antonello

  • Emily P Balskus

  • David T Booth

  • Søren B Christensen

  • Ed Cleator

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