A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed azide-alkyne cycloaddition. The methodology efficiently provides chemically uniform heteromultimeric peptide constructs with enhanced binding, avidity, and specificity toward an established HIV-neutralizing human antibody, MAb b12. The versatile synthetic strategy serves as a powerful platform for the development of synthetic peptides as potential HIV-1 vaccine candidates. © 2011 American Chemical Society.
CITATION STYLE
Schellinger, J. G., Danan-Leon, L. M., Hoch, J. A., Kassa, A., Srivastava, I., Davis, D., & Gervay-Hague, J. (2011). Synthesis of a trimeric gp120 epitope mimic conjugated to a T-helper peptide to improve antigenicity. Journal of the American Chemical Society, 133(10), 3230–3233. https://doi.org/10.1021/ja1083915
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