Synthesis of a trimeric gp120 epitope mimic conjugated to a T-helper peptide to improve antigenicity

  • Schellinger J
  • Danan-Leon L
  • Hoch J
 et al. 
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Abstract

A fully synthetic trivalent mimotope of gp120 conjugated to pan allelic HLA DR binding epitope was prepared using solid-phase peptide synthesis and optimized copper-catalyzed azide-alkyne cycloaddition. The methodology efficiently provides chemically uniform heteromultimeric peptide constructs with enhanced binding, avidity, and specificity toward an established HIV-neutralizing human antibody, MAb b12. The versatile synthetic strategy serves as a powerful platform for the development of synthetic peptides as potential HIV-1 vaccine candidates.

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Authors

  • Joan G. Schellinger

  • Lieza M. Danan-Leon

  • Jessica A. Hoch

  • Aemro Kassa

  • Indresh Srivastava

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