Synthesis and in vitro activity of new tetrahydronaphtho[1,2-b]azepine derivatives against Trypanosoma cruzi and Leishmania chagasi parasites

  • Palma A
  • Yépes A
  • Leal S
 et al. 
  • 20

    Readers

    Mendeley users who have this article in their library.
  • 30

    Citations

    Citations of this article.

Abstract

Series of 2-exo-aryl-1,4-epoxy-2,3,4,5-tetrahydronaphtho[1,2-b]azepines 3a-k and cis-2-aryl-4-hydroxy-2,3,4,5-tetrahydronaphtho[1,2-b]azepines 4a-j were synthesized and evaluated against free and intracellular live forms of Trypanosoma cruzi and Leishmania chagasi parasites using in vitro assays. Cell toxicity was also analyzed on Vero and THP-1 mammalian cell lines. The compounds 3c, 3f, and 4d were the most active against both live forms of T. cruzi parasites with low mammalian cell toxicity. Some compounds were active on free live forms of L. chagasi parasites but none was active on intracellular amastigotes of L. chagasi infecting THP-1 macrophages. © 2008 Elsevier Ltd. All rights reserved.

Author-supplied keywords

  • 1,4-Epoxytetrahydronaphtho[1,2-b]azepines
  • Anti-parasitic agents
  • Chagas' disease
  • Drug discovery
  • Leishmania chagasi
  • Tetrahydronaphtho[1,2-b]azepines
  • Trypanosoma cruzi

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Alirio Palma

  • Andrés Felipe Yépes

  • Sandra Milena Leal

  • Carlos Andrés Coronado

  • Patricia Escobar

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free