Synthetic "chaperones": nanoparticle-mediated refolding of thermally denatured proteins.

  • De M
  • Rotello V
  • 60


    Mendeley users who have this article in their library.
  • 52


    Citations of this article.


Thermally denatured chymotrypsin, lysozyme and papain are substantially refolded towards their native conformation by gold nanoparticle bearing dicarboxylate sidechains.

Author-supplied keywords

  • Circular Dichroism
  • Gold
  • Gold: chemistry
  • Gold: pharmacology
  • Hot Temperature
  • Hydrolases
  • Hydrolases: chemistry
  • Hydrolases: metabolism
  • Hydrophobic and Hydrophilic Interactions
  • Metal Nanoparticles
  • Metal Nanoparticles: chemistry
  • Models
  • Molecular
  • Protein Conformation
  • Protein Denaturation
  • Protein Folding
  • Protein Renaturation
  • Protein Renaturation: drug effects

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Mrinmoy De

  • Vincent M Rotello

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free