Synthetic "chaperones": nanoparticle-mediated refolding of thermally denatured proteins.

  • De M
  • Rotello V
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Abstract

Thermally denatured chymotrypsin, lysozyme and papain are substantially refolded towards their native conformation by gold nanoparticle bearing dicarboxylate sidechains.

Author-supplied keywords

  • Circular Dichroism
  • Gold
  • Gold: chemistry
  • Gold: pharmacology
  • Hot Temperature
  • Hydrolases
  • Hydrolases: chemistry
  • Hydrolases: metabolism
  • Hydrophobic and Hydrophilic Interactions
  • Metal Nanoparticles
  • Metal Nanoparticles: chemistry
  • Models
  • Molecular
  • Protein Conformation
  • Protein Denaturation
  • Protein Folding
  • Protein Renaturation
  • Protein Renaturation: drug effects

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Authors

  • Mrinmoy De

  • Vincent M Rotello

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