Systematic evaluation of single-use systems using process simulation tools

  • Papavasileiou V
  • Siletti C
  • Petrides D
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The choice of single-use versus stainless-steel systems depends on a variety of process and other parameters such as bioreactor scale, product titer, and product changeover frequency. Computer-aided process design and simulation tools facilitate analysis and evaluation of process alternatives and assist scientists and engineers in their decision-making process. This article describes the steps required to build a comprehensive model in a batch process simulator for a process that uses single-use systems for buffer preparation and storage. The process is subsequently compared to a traditional method using stainless-steel tanks. The impact of single-use systems on production costs, demand for cleaning materials and consumables, and the cycle time of the process is thoroughly evaluated.

Author-supplied keywords

  • article
  • batch process
  • bioreactor
  • cleaning
  • computer aided design
  • computer simulation
  • decision making
  • disposable equipment
  • economic aspect
  • financial management
  • intermethod comparison
  • materials handling
  • process model
  • scale up
  • stainless steel

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  • V Papavasileiou

  • C Siletti

  • D Petrides

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