Systematic review of the evidence underlying the association between mineral metabolism disturbances and risk of all-cause mortality, cardiovascular mortality and cardiovascular events in chronic kidney disease

  • Covic A
  • Kothawala P
  • Bernal M
 et al. 
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Chronic kidney disease (CKD) is a powerful risk factor for all-cause mortality and its most common aetiology, cardiovascular (CV) mortality. Mineral metabolism disturbances occur very early during the course of CKD but their control has been poor. A number of studies have assessed the relationship between all-cause mortality, CV mortality and events with mineral disturbances in CKD patients, but with considerable discrepancy and heterogeneity in results. Thus, a systematic review was conducted to assess methodological and clinical heterogeneity by comparing designs, analytical approaches and results of studies.

Author-supplied keywords

  • Chronic kidney disease
  • Dialysis
  • Mineral metabolism disturbances
  • Risk of cardiovascular mortality
  • Risk of mortality

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  • Adrian Covic

  • Prajesh Kothawala

  • Myriam Bernal

  • Sean Robbins

  • Arpi Chalian

  • David Goldsmith

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