The Systemic Inflammatory Response Syndrome in Patients With ST-Segment Elevation Myocardial Infarction

  • Sean van D
  • John P V
  • Kristin N
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Objective: To clarify the effect of progressively increasing intra-abdominal pressure on esophageal pressure, transpulmonary pressure, and functional residual capacity. Design: Controlled application of increased intra-abdominal pres-sure at two positive end-expiratory pressure levels (1 and 10 cm HjO) in an anesthetized porcine model of controlled ventilation. Setting: Large animal laboratory of a university-affiliated hospital. Subjects: Eleven deeply anesthetized swine (weight 46.2 ±6.2 kg). Interventions: Air-regulated intra-abdominal hypertension (0-25 mmHg). Measurements: Esophageal pressure, tidal compliance, bladder pressure, and end-expiratory lung aeration by gas dilution. Main Resuits: Functional residual capacity was significantly reduced by increasing intra-abdominal pressure at both positive end-expiratory pressure levels (p

Author-supplied keywords

  • fluid challenge
  • oxygen consumption
  • oxygénation
  • shock
  • tissue
  • veno-arterial carbon dioxide gap
  • venous oxygen

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  • Diepen Sean van

  • Vacalle John P

  • Newby Kristin

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