Systemic Lupus Erythematosus in Children and Adolescents

  • Levy, DM Kamphuis S
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Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of disease manifestations that can involve any organ system, and can lead to significant morbidity and even mortality. This article reviews the epidemiology, common clinical features, and complications of the disease, and briefly discusses the available treatment options. In addition, important medical and psychosocial issues relevant to the pediatrician caring for children and adolescents with SLE are discussed. © 2012 Elsevier Inc..

Author-supplied keywords

  • La antibody
  • Meningococcus vaccine
  • Pneumococcus vaccine
  • Ro antibody
  • Sm antibody
  • acetylsalicylic acid
  • adolescent
  • adverse outcome
  • antibiotic agent
  • antibody production
  • anticonvulsive agent
  • antidepressant agent
  • antinuclear antibody
  • aralen
  • arthritis
  • autoimmune disease
  • avascular necrosis
  • azathioprine
  • bacterial infection
  • belimumab
  • benlysta
  • cellcept
  • child
  • child health care
  • chloroquine
  • clinical feature
  • cognitive defect
  • confusion
  • contraceptive agent
  • corticosteroid
  • cyclophosphamide
  • cyclosporin
  • cytopenia
  • cytoxan
  • daily life activity
  • differential diagnosis
  • disease classification
  • disease course
  • disease severity
  • double stranded DNA antibody
  • drug efficacy
  • drug megadose
  • drug safety
  • early diagnosis
  • ethnic difference
  • gastrointestinal disease
  • glomerulonephritis
  • headache
  • heart disease
  • hematologic disease
  • high risk population
  • human
  • hydroxychloroquine
  • immunocompromized patient
  • immunoglobulin
  • immunosuppressive agent
  • imuran
  • infection risk
  • inflammation
  • influenza
  • influenza vaccine
  • kidney disease
  • kidney failure
  • laboratory test
  • long term care
  • lung disease
  • lupus erythematosus nephritis
  • macrophage activation syndrome
  • meningococcosis
  • mental disease
  • methotrexate
  • mood disorder
  • morbidity
  • mortality
  • musculoskeletal disease
  • mycophenolate mofetil
  • nonsteroid antiinflammatory agent
  • onset age
  • plaquenil
  • pneumococcal infection
  • prednisone
  • psychosis
  • psychotropic agent
  • quality of life
  • rash
  • renal replacement therapy
  • review
  • ribonucleoprotein antibody
  • risk benefit analysis
  • rituxan
  • rituximab
  • seizure
  • social psychology
  • survival rate
  • systemic lupus erythematosus
  • treatment duration
  • unindexed drug
  • vascular disease
  • vasculitic rash
  • virus infection

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Authors

  • S Levy, DM Kamphuis

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