Targeted genome editing across species using ZFNs and TALENs

  • Wood A
  • Lo T
  • Zeitler B
 et al. 
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Abstract

Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.

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Authors

  • Andrew J. Wood

  • Te Wen Lo

  • Bryan Zeitler

  • Catherine S. Pickle

  • Edward J. Ralston

  • Andrew H. Lee

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