Targeted genome editing across species using ZFNs and TALENs

  • Wood A
  • Lo T
  • Zeitler B
 et al. 
  • 709


    Mendeley users who have this article in their library.
  • 375


    Citations of this article.


Evolutionary studies necessary to dissect diverse biological processes have been limited by the lack of reverse genetic approaches in most organisms with sequenced genomes. We established a broadly applicable strategy using zinc finger nucleases (ZFNs) and transcription activator-like effector nucleases (TALENs) for targeted disruption of endogenous genes and cis-acting regulatory elements in diverged nematode species.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Andrew J. Wood

  • Te Wen Lo

  • Bryan Zeitler

  • Catherine S. Pickle

  • Edward J. Ralston

  • Andrew H. Lee

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free