Journal article

Targeting therapeutic and imaging agents to folate receptor positive tumors.

Reddy J, Allagadda V, Leamon C ...see all

Current pharmaceutical biotechnology, vol. 6, issue 2 (2005) pp. 131-50

  • 18


    Mendeley users who have this article in their library.
  • 98


    Citations of this article.
Sign in to save reference


The membrane-bound folate receptor (FR) is overexpressed on a wide range of human cancers, such as those originating in ovary, lung, breast, endometrium, kidney and brain. The vitamin folic acid is a high affinity ligand of the FR which retains its receptor binding properties when conjugated to other molecules. Consequently, "folate targeting" technology has successfully been applied for the delivery of protein toxins, chemotherapeutic agents, radio-imaging and therapeutic agents, MRI contrast agents, liposomes, gene transfer vectors, antisense oligonucleotides, ribozymes and immunotherapeutic agents to FR-positive cancers. These folate-bearing delivery systems have produced major enhancements in cancer cell specificity and selectivity over their non-targeted formulation counterparts. Hence, it is hopeful that this targeting strategy will lead to improvements in the safety and efficacy of clinically-relevant anti-cancer agents. Therefore, the focus of this review will be to highlight the current status of folate-targeted technology with particular emphasis on the recent advances in this field as well as possible directions for future development.

Author-supplied keywords

  • Animals
  • Antineoplastic Agents
  • Antineoplastic Agents: administration & dosage
  • Carrier Proteins
  • Carrier Proteins: metabolism
  • Contrast Media
  • Drug Delivery Systems
  • Drug Delivery Systems: methods
  • Drug Design
  • Folate Receptors, GPI-Anchored
  • Gene Therapy
  • Gene Therapy: methods
  • Humans
  • Immunotherapy
  • Immunotherapy: methods
  • Neoplasms
  • Neoplasms: metabolism
  • Neoplasms: radionuclide imaging
  • Neoplasms: therapy
  • Receptors, Cell Surface
  • Receptors, Cell Surface: metabolism
  • Tumor Markers, Biological
  • Tumor Markers, Biological: metabolism

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • J a Reddy

  • V M Allagadda

  • C P Leamon

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free