No taste for methyl: Methylation sensitive proteolysis in drug screening

  • Bissinger E
  • Jung M
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Abstract

Methyltransferases and demethylases are emerging targets for epigenetic therapy. Wigle et al. (2010) present a new assay for the enzyme inhibition of methyltransferases and demethylases based on selective enzymatic cleavage of unmethylated versus methylated peptides and their subsequent electrophoretic separation. © 2010 Elsevier Ltd.

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Authors

  • Elisabeth Maria Bissinger

  • Manfred Jung

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