Taxol: a history of pharmaceutical development and current pharmaceutical concerns.

  • Adams J
  • Flora K
  • Goldspiel B
 et al. 
  • 7


    Mendeley users who have this article in their library.
  • 143


    Citations of this article.


Taxol, a unique diterpene anticancer compound derived from the bark of the Taxus brevifolia (Pacific yew) tree, induces cytotoxicity by a novel mechanism of action. An antimicrotubule agent, Taxol promotes the formation and stabilization of the tubulin polymer unlike other anticancer agents that induce microtubule disassembly. Because of its poor aqueous solubility, Taxol is formulated as a solution in 50% Cremophor EL and 50% dehydrated alcohol, USP. The Cremophor EL and dehydrated alcohol vehicle used in the formulation of Taxol creates some interesting challenges for its preparation and administration. The pharmaceutical concerns associated with the preparation and administration of Taxol are discussed.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 7912520
  • SGR: 0027862597
  • SCOPUS: 2-s2.0-0027862597
  • PUI: 24910914
  • ISBN: 1052-6773
  • ISSN: 10526773


  • J D Adams

  • K P Flora

  • B R Goldspiel

  • J W Wilson

  • S G Arbuck

  • R Finley

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free