tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

  • Kikuchi K
  • Gupta V
  • Wang J
 et al. 
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Recent lineage-tracing studies have produced conflicting results about whether the epicardium is a source of cardiac muscle cells during heart development. Here, we examined the developmental potential of epicardial tissue in zebrafish during both embryonic development and injury-induced heart regeneration. We found that upstream sequences of the transcription factor gene tcf21 activated robust, epicardium-specific expression throughout development and regeneration. Cre recombinase-based, genetic fate-mapping of larval or adult tcf21(+) cells revealed contributions to perivascular cells, but not cardiomyocytes, during each form of cardiogenesis. Our findings indicate that natural epicardial fates are limited to non-myocardial cell types in zebrafish.

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  • K. Kikuchi

  • V. Gupta

  • J. Wang

  • J. E. Holdway

  • A. A. Wills

  • Y. Fang

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