Telomerase and cancer: Revisiting the telomere hypothesis

  • Autexier C
  • Greider C
  • 56

    Readers

    Mendeley users who have this article in their library.
  • 159

    Citations

    Citations of this article.

Abstract

Telomerase is a ribonucleoprotein DNA polymerase that elongates telomeres in eukaryotes. The telomere hypothesis implicates short telomere length and telomerase activation as critical players in cellular immortalization and cancer. In this review, we refine the original telomere hypothesis to address the results of recent studies on telomerase and telomere length regulation.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Chantal Autexier

  • Carol W. Greider

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free