Telomerase unplugged

  • Cristofari G
  • Sikora K
  • Lingner J
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The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

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  • Gaël Cristofari

  • Katarzyna Sikora

  • Joachim Lingner

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