Telomere shortening in familial and sporadic pulmonary fibrosis.

  • Cronkhite J
  • Xing C
  • Raghu G
 et al. 
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Heterozygous mutations in the coding regions of the telomerase genes, TERT and TERC, have been found in familial and sporadic cases of idiopathic interstitial pneumonia. All affected patients with mutations have short telomeres.

Author-supplied keywords

  • 80 and over
  • Adult
  • Aged
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease
  • Genetic Predisposition to Disease: genetics
  • Humans
  • Male
  • Middle Aged
  • Missense
  • Mutation
  • Pedigree
  • Pulmonary Fibrosis
  • Pulmonary Fibrosis: genetics
  • RNA
  • RNA: genetics
  • Regeneration
  • Regeneration: genetics
  • Telomerase
  • Telomerase: genetics
  • Telomere
  • Telomere: pathology

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  • Jennifer T Cronkhite

  • Chao Xing

  • Ganesh Raghu

  • Kelly M Chin

  • Fernando Torres

  • Randall L Rosenblatt

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