Temporal changes in allele frequencies provide estimates of population bottleneck size

  • Luikart G
  • Cornuet J
  • Allendorf F
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Abstract

Monitoring temporal changes in genetic variation can provide estimates of effective population size (N-c) that are useful for detecting population bottlenecks. We used Monte Carlo computer simulations to quantify the bias and precision of the N-c estimates obtained from temporal changes in allele frequencies at allozyme and microsatellite loci. The estimates of N-c overestimated the true N-c by 12-200% after 1-10 generations of a bottleneck of effective size 4. This magnitude of bias, however, is not likely to cause bottlenecks to go undetected or to cause misguided management recommendations. The bias was nearly negligible for bottlenecks of effective size greater than or equal to 10, until approximately five bottleneck generations had passed. Three causes of the bias are the loss of alleles, the assumption that the increase in variance in allele frequencies with time is additive (instead of multiplicative), and the assumption that selfing can occur when it cannot. We derived a new equation that substantially reduces the bias. The precision of N-c estimates was sufficient that, when true N-c was 4, the 95% confidence interval bracketing a N-c estimate was

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Authors

  • Gordon Luikart

  • Jean Marie Cornuet

  • Fred W. Allendorf

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