Therapeutic targeting of innate immunity with Toll-like receptor agonists and antagonists

  • Kanzler H
  • Barrat F
  • Hessel E
 et al. 
  • 1


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


The identification of the antigen recognition receptors for innate immunity, most notably the Toll-like receptors, has sparked great interest in therapeutic manipulation of the innate immune system. Toll-like receptor agonists are being developed for the treatment of cancer, allergies and viral infections, and as adjuvants for potent new vaccines to prevent or treat cancer and infectious diseases. As recognition grows of the role of inappropriate Toll-like receptor stimulation in inflammation and autoimmunity, significant efforts have begun to develop antagonists to Toll-like receptors as well.

Author-supplied keywords

  • *Immunity, Natural
  • Animals
  • Antigens/immunology
  • Autoimmunity
  • Humans
  • Hypersensitivity/immunology
  • Inflammation/immunology
  • Models, Immunological
  • Neoplasms/immunology
  • Toll-Like Receptors/agonists/antagonists & inhibit
  • Virus Diseases/immunology

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

  • PMID: 17479101


  • H Kanzler

  • F J Barrat

  • E M Hessel

  • R L Coffman

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free