Theta sequences are essential for internally generated hippocampal firing fields

  • Wang Y
  • Romani S
  • Lustig B
 et al. 
  • 297


    Mendeley users who have this article in their library.
  • 66


    Citations of this article.


Sensory cue inputs and memory-related internal brain activities govern the firing of hippocampal neurons, but which specific firing patterns are induced by either of the two processes remains unclear. We found that sensory cues guided the firing of neurons in rats on a timescale of seconds and supported the formation of spatial firing fields. Independently of the sensory inputs, the memory-related network activity coordinated the firing of neurons not only on a second-long timescale, but also on a millisecond-long timescale, and was dependent on medial septum inputs. We propose a network mechanism that might coordinate this internally generated firing. Overall, we suggest that two independent mechanisms support the formation of spatial firing fields in hippocampus, but only the internally organized system supports short-timescale sequential firing and episodic memory.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Yingxue Wang

  • Sandro Romani

  • Brian Lustig

  • Anthony Leonardo

  • Eva Pastalkova

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free