Three new glutarimide alkaloids from Croton cuneatus

  • Suárez A
  • Blanco Z
  • Delle Monache F
 et al. 
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Abstract

Analysis of the dichloromethane extract of the aerial parts of Croton cuneatus led to the isolation of the new glutarimide alkaloids: julocrotol (1), isojulocrotol (2), and julocrotone (3) along with the known compounds julocrotonine (4), lichexanthone (5) and selin-11-en-4alpha-ol (6). The structures of the new compounds were established by spectral methods. The in vitro cytotoxic activity of Compounds 1-6 was evaluated against six human tumor cells lines.

Author-supplied keywords

  • Alkaloids
  • Croton cuneatus
  • Cytotoxic
  • Euphorbiaceae

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Authors

  • Alírica I. Suárez

  • Zuleyma Blanco

  • Franco Delle Monache

  • Reinaldo S. Compagnone

  • Francisco Arvelo

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