Three years follow-up results of ranibizumab treatment for choroidal neovascularization secondary to pathologic myopia

  • Hefner L
  • Riese J
  • Gerding H
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Background: Choroidal neovascularization (CNV) secondary to pathological
myopia (PM) is one of the main causes of severe visual impairment in
patients younger than 50 years. In this analysis we want to demonstrate
the long-term results of Ranibizumab treating CNV secondary to PM.
Patients and Methods: We retrospectively analysed 15 treatment naive
eyes of 13 patients (10 women, 3 men, mean age: 61.5, SD 11.6, range:
41-80) with visual impairment due to CNV secondary to PM, which were
treated with ranibizumab. Criteria for re-treatment were reduction of
visual acuity and/or activity in OCT or fluorescence angiography.
Results: We applied a mean of 3 injections (standard deviation {[}SD]
2.5, range: 1-8) ranibizumab during a mean period of 39.6 months (SD
5.3, range: 31-52). The spherical equivalent was -12.4 diopters +/- 4.1
(range -7.5 to -20.5 diopters). Before the first injection mean visual
acuity (logMAR) was 0.69 +/- 0.26. After one month visual acuity
improved to 0.39 +/- 0.23 (p = 0.002), after 3 months to 0.30 +/- 0.22
(p = 0.002) and after 6 months up to 0.30 +/- 0.22 (p = 0.002). After 12
months visual acuity was 0.30 +/- 0.22 (p = 0.001) and after 24 months
0.30 +/- SD 0.24 (p = 0.001). 11 patients reached a follow-up of at
least 36 months and visual acuity was 0.30 +/- 0.13 (p = 0,001).
Conclusions: Treating CNV secondary to PM with ranibizumab during a
follow-up of 36 months, we found considerable improvement of visual
acuity. Compared to treatment of CNV secondary to exudative age-related
macular degeneration, CNVs secondary to PM seem to respond faster to
ranibizumab treatment and less injections are neccessary to reach

Author-supplied keywords

  • Lucentis
  • Ranibizumab
  • anti-VEGF
  • choroidal neovascularization (CNV)
  • pathologic myopia (PM)

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  • L. Hefner

  • J. Riese

  • H. Gerding

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