Three-dimensional nonlinear optical endoscopy.

  • Fu L
  • Jain A
  • Cranfield C
 et al. 
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The development of miniaturized nonlinear optical microscopy or endoscopy is essential to complement the current imaging modalities for diagnosis and monitoring of cancers. We report on a nonlinear optical endoscope based on a double-clad photonic crystal fiber and a two-dimensional (2-D) microelectromechanical system mirror, enabling the three-dimensional (3-D) nonlinear optical imaging through in vitro gastrointestinal tract tissue and human breast cancer tissue with a penetration depth of approximately 100 mum and axial resolution of 10 mum. The 3-D high-resolution and high-sensitive imaging ability of the nonlinear optical endoscope facilitates the visualization of 3-D morphologic and cell nuclei arrangement within tissue, and therefore will be important for histopathologic interpretation without the need of tissue excision.

Author-supplied keywords

  • 17
  • 2007
  • dimensional ͑ 3-d ͒
  • endoscopy
  • microelectromechanical system ͑ mems
  • nonlinear optical microscopy
  • paper 07021lrr received jan
  • photonic crys-
  • revised manuscript received
  • tal fiber
  • three-
  • tissue imaging
  • ͒ mirror

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  • Ling Fu

  • Ankur Jain

  • Charles Cranfield

  • Huikai Xie

  • Min Gu

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