The thrombogram: monitoring thrombin generation in platelet-rich plasma.

  • Hemker H
  • Giesen P
  • Ramjee M
 et al. 
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A method is described in which thrombin activity in clotting plasma can be monitored through the continuous measurement of the fluorescent split-product of the substrate Z-Gly-Gly-Arg-AMC. The signal is not impaired by turbidity; therefore proper measurement is not disturbed by the occurrence of a clot or the presence of platelets and direct measurement in platelet rich plasma is possible.

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  • H C Hemker

  • P L Giesen

  • M Ramjee

  • R Wagenvoord

  • S Béguin

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