Is topical zinc effective in the treatment of melasma? A double-blind randomized comparative study

  • Yousefi A
  • Khani Khoozani Z
  • Zakerzadeh Forooshani S
 et al. 
  • 13


    Mendeley users who have this article in their library.
  • 5


    Citations of this article.


BACKGROUND AND OBJECTIVES: Zinc plays a role in skin health, and preliminary data have shown its beneficial effects for melasma. We compared the effect of topical zinc with that of hydroquinone as the standard treatment on severity of melasma.

PATIENTS AND METHODS: Ninety-three women with melasma were randomized to receive zinc sulfate 10% or hydroquinone 4% solutions once daily for 2 months. They were followed for an additional 3 months while using sunscreen. The severity of melasma was assessed at baseline and at 2 and 5 months using the Melasma Area and Severity Index (MASI).

RESULTS: Eighty-two patients completed the study. The MASI score fell significantly in both groups, but a greater decrease was seen in those who received hydroquinone (43.5 ± 15.5% vs 18.6 ± 20.8%, p 
CONCLUSION: Topical zinc therapy is not highly effective in reducing the severity of melasma, but further trials are needed to determine whether adding zinc to current topical treatments could improve treatment response.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Get full text


  • Alireza Yousefi

  • Zahra Khani Khoozani

  • Saeed Zakerzadeh Forooshani

  • Nooshin Omrani

  • Amir Mansoor Moini

  • Yasaman Eskandari

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free