Topiramate: Effect on EEG interictal abnormalities and background activity in patients affected by focal epilepsy

  • Placidi F
  • Tombini M
  • Romigi A
 et al. 
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Purpose: To evaluate the effects of topiramate (TPM) on interictal epileptiform abnormalities (IEA) and background activity by means of a computerized EEG analysis, in adult patients affected by focal epilepsy, with or without secondarily generalization, treated with TPM as adjunctive therapy or monotherapy. Methods: Twenty-four patients affected by symptomatic or cryptogenic focal epilepsy underwent long-term video-EEG recording before and after TPM addition (mean dose 175±25mg per day). Results: TPM addition induced a significant reduction of both partial and secondarily generalized tonic-clonic (SGTC) seizures; treatment responder patients (seizure reduction≥50%) were 19 out of 24 patients (79.1%), of whom 5 were seizure-free. Quantitative analysis of IEA showed a significant decrease in the mean number of spikes/10min during TPM therapy (4.2±4.2 versus 2.2±4.4; P

Author-supplied keywords

  • Background activity
  • EEG
  • Focal epilepsy
  • Interictal epileptiform abnormalities (IEA)
  • Topiramate

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