Topography of cerebral atrophy in early Huntington's disease: a voxel based morphometric MRI study.

  • Kassubek J
  • Juengling F
  • Kioschies T
 et al. 
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OBJECTIVES: To analyse grey matter changes in early stages of Huntington's disease using magnetic resonance imaging (MRI) and the technique of voxel based morphometry (VBM). METHODS: Forty four patients with a molecularly confirmed clinical diagnosis of Huntington's disease based on the presence of motor signs were included in the study. Patients were clinically rated using the Unified Huntington's Disease Rating Scale; all were in early clinical stages of the disease (that is, Shoulson stages I and II). High resolution volume rendering MRI scans (MP-RAGE) were acquired. MRI data were volumetrically analysed in comparison to an age matched normal database by VBM, using statistical parametric mapping (SPM99). RESULTS: In Huntington's disease, robust regional decreases in grey matter density (p

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  • J. Kassubek

  • F.D. D Juengling

  • T. Kioschies

  • K. Henkel

  • J. Karitzky

  • B. Kramer

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