Total synthesis of (±)-prostagladin D1: Use of triethylsilyl protecting groups

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Abstract

(±)-Prostaglandin D1 has been synthesised by oxidation of (±)-PGF1α 15-t-butyldimethylsilyl ether and also of its 9-triethylsilyl ether; preparation and selective hydrolysis of triethylsilyl ethers are key steps in the sequence.

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Hart, T. W., Metcalfe, D. A., & Scheinmann, F. (1979). Total synthesis of (±)-prostagladin D1: Use of triethylsilyl protecting groups. Journal of the Chemical Society, Chemical Communications, (4), 156–157. https://doi.org/10.1039/C39790000156

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