Toward optimizing lighting as a countermeasure to sleep and circadian disruption in space flight

  • Fucci R
  • Gardner J
  • Hanifin J
 et al. 
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Light is being used as a pre-launch countermeasure to circadian and sleep disruption in astronauts. The effect of light on the circadian system is readily monitored by measurement of plasma melatonin. Our group has established an action spectrum for human melatonin regulation and determined the region of 446-477 nm to be the most potent for suppressing plasma melatonin. The aim of this study was to compare the efficacy of 460 and 555 nm for suppressing melatonin using a within-subjects design. Subjects (N=12) were exposed to equal photon densities (7.18×1012photons/cm2/s) at 460 and 555 nm. Melatonin suppression was significantly stronger at 460 nm (p

Author-supplied keywords

  • Astronauts
  • Circadian
  • Countermeasure
  • Light
  • Melatonin
  • Pineal

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  • Robert L. Fucci

  • James Gardner

  • John P. Hanifin

  • Samar Jasser

  • Brenda Byrne

  • Edward Gerner

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