Toward precision medicine in glioblastoma: The promise and the challenges

  • Prados M
  • Byron S
  • Tran N
 et al. 
  • 124


    Mendeley users who have this article in their library.
  • 60


    Citations of this article.


Integrated sequencing strategies have provided a broader understanding of the genomic landscape and molecular classifications of multiple cancer types and have identified various therapeutic opportunities across cancer subsets. Despite pivotal advances in the characterization of genomic alterations in glioblastoma, targeted agents have shown minimal efficacy in clinical trials to date, and patient survival remains poor. In this review, we highlight potential reasons why targeting single alterations has yielded limited clinical efficacy in glioblastoma, focusing on issues of tumor heterogeneity and pharmacokinetic failure. We outline strategies to address these challenges in applying precision medicine to glioblastoma and the rationale for applying targeted combination therapy approaches that match genomic alterations with compounds accessible to the central nervous system.

Author-supplied keywords

  • Clinical trial
  • Genomics
  • Glioblastoma
  • Precision medicine
  • Targeted therapy

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document


  • Michael D. Prados

  • Sara A. Byron

  • Nhan L. Tran

  • Joanna J. Phillips

  • Annette M. Molinaro

  • Keith L. Ligon

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free