Toxicological analysis of a fatal baclofen (Lioresal) ingestion.

  • Fraser A
  • MacNeil W
  • Isner A
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A fatality following ingestion of the drug baclofen (Lioresal) is described. Baclofen was identified in urine by gas chromatography/mass spectrometry. After derivatization with trinitrobenzene sulfonic acid, baclofen was quantitated in serum and urine by high-performance liquid chromatography. The concentration of baclofen was 17 mg/L in serum and 760 mg/L in urine collected approximately 12 h after the overdose. To our knowledge, this is only the second reported fatality involving a baclofen overdose. The previous case did not include quantitation of baclofen in any biological fluid.

Author-supplied keywords

  • Adult
  • Baclofen
  • Baclofen: blood
  • Baclofen: poisoning
  • Baclofen: urine
  • Chromatography, High Pressure Liquid
  • Chromatography, Thin Layer
  • Drug Overdose
  • Drug Overdose: pathology
  • Gas Chromatography-Mass Spectrometry
  • Humans
  • Male
  • Quadriplegia
  • Quadriplegia: drug therapy

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  • a D Fraser

  • W MacNeil

  • a F Isner

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