Hypothesis: The fall in haemoglobin following unilateral total knee arthroplasty is reduced by tranexamic acid administration. Methods: 60 patients were studied in total, 30 received tranexamic acid 10 mg/kg on induction and a further dose shortly before the release of the tourniquet. Surgery was performed by the senior author in a standardised fashion using the Freeman Samuelson cemented total knee replacement. Haemoglobin levels were measured 2 weeks pre and 3 days post operatively. Any complications were noted. A control group was matched using the Bone and Joint Research Unit database for age, sex, disease and pre-operative haemoglobin level. This group had been monitored in the same way as the group treated with tranexamic acid. Results: In the group receiving no tranexamic acid the mean fall in haemoglobin was 2.8 g/dl (95% CI of mean 2.5-3.2) and in the group treated with tranexamic acid 1.7 g/dl (95% CI of mean 1.3-2) P<0.01. There were no complications in either group. Conclusions: The administration of tranexamic acid is an effective method of reducing the haemoglobin fall following knee arthroplasty. © 2003 Elsevier B.V. All rights reserved.
CITATION STYLE
Hynes, M., Calder, P., & Scott, G. (2003). The use of tranexamic acid to reduce blood loss during total knee arthroplasty. Knee, 10(4), 375–377. https://doi.org/10.1016/S0968-0160(03)00044-9
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