Transcranial Doppler ultrasonography and neurocognitive functioning in children with sickle cell disease.

  • MC K
  • RT B
  • PJ N
 et al. 
  • 2


    Mendeley users who have this article in their library.
  • N/A


    Citations of this article.


OBJECTIVE: We examined the relationship between cerebral blood flow velocity, measured by transcranial Doppler (TCD) ultrasonography, and neurocognitive functioning. METHODS: Participants were 60 children who had sickle cell disease (HbSS) and had no documented history of stroke. Children were classified according to Stroke Prevention Trial in Sickle Cell Anemia criteria (normal, conditional, and abnormal), and their performance was compared on measures of intellectual abilities, academic achievement, sustained attention/concentration, executive function, and parent and teacher ratings of executive function. RESULTS: Children with abnormal TCD values performed more poorly than children with conditional TCD values on measures of verbal intelligence and executive function. Children with conditional TCD values performed more poorly than children with normal TCD values on measures of sustained attention/concentration and executive function. TCD values also were a significant predictor of auditory working memory in exploratory analyses. CONCLUSIONS: Our findings support the hypothesis that neurocognitive functions subserved by the frontal systems (eg, sustained attention/concentration and executive function) seem to be the most useful indices of progressive cerebrovasculopathy in children with HbSS disease.

Author-supplied keywords

  • Adolescent
  • Anemia, Sickle Cell/pp [Physiopathology]
  • Anemia, Sickle Cell/px [Psychology]
  • Anemia, Sickle Cell/us [Ultrasonography]
  • Blood Flow Velocity
  • Cerebrovascular Circulation
  • Child
  • Cognition
  • Female
  • Humans
  • Intelligence
  • Male
  • Multivariate Analysis
  • Psychological Tests
  • Regression Analysis
  • Socioeconomic Factors
  • Ultrasonography, Doppler, Transcranial

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in


  • Kral MC

  • Brown RT

  • Nietert PJ

  • Abboud MR

  • Jackson SM

  • Hynd GW

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free