Transient partial response to sorafenib treatment in an adolescent patient with MEN2B Syndrome and end-stage medullary thyroid carcinoma

  • Aller S
  • Popescu A
  • Rao S
 et al. 
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Abstract

Metastatic medullary thyroid carcinoma (MTC) is an aggressive malignancy with an extremely poor prognosis. Currently no effective conventional systemic therapies exist to treat pediatric MTC. We describe an adolescent female with newly diagnosed MEN2B syndrome who presented with advanced stage metastatic MTC and demonstrated a partial transient response to sorafenib monotherapy. This clinical result supports further research into the use of sorafenib in the treatment of pediatric MTC. © 2011 Wiley Periodicals, Inc.

Author-supplied keywords

  • MEN2B syndrome
  • Metastatic medullary thyroid carcinoma
  • Sorafenib

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Authors

  • Steven Aller

  • Andrada Popescu

  • Sudha Rao

  • Elaine Morgan

  • Yasmin Gosiengfiao

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