Transient renal effects of sildenafil in male kidney transplant recipients.

  • Malavaud B
  • Rostaing L
  • Tran-Van T
 et al. 
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BACKGROUND: Sildenafil (Viagra) improves erection by sustaining Guanosine 3', 5'-cyclic monophosphate (cGMP)-mediated smooth muscle relaxation in the corpus cavernosum. It also induces systemic vasodilation, resulting in a minor decrease in blood pressure. We evaluated the effect of one dose of sildenafil on graft function and hemodynamics in impotent male transplant recipients. METHODS: Two sets of combined lithium, inulin, and p-amino hippurate clearance studies were conducted, with and without sildenafil (100 mg orally) in 11 male kidney transplant recipients (KTRs). RESULTS: Sildenafil increased glomerular filtration rate by 14+/-4 from the baseline value of 55+/-7 ml x min(-1) x 1.73 m2(-1) (P

Author-supplied keywords

  • Erectile Dysfunction
  • Glomerular Filtration Rate
  • Humans
  • Kidney
  • Kidney Transplantation
  • Male
  • Middle Aged
  • Phosphodiesterase Inhibitors
  • Piperazines
  • Postoperative Period
  • Purines
  • Renal Circulation
  • Sildenafil Citrate
  • Sulfones
  • Time Factors
  • Vascular Resistance
  • drug effects
  • drug therapy
  • therapeutic use

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  • B Malavaud

  • L Rostaing

  • T Tran-Van

  • I Tack

  • J L Ader

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