Translational research in atrial fibrillation: A quest for mechanistically based diagnosis and therapy

  • Atienza F
  • Martins R
  • Jalife J
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Atrial fibrillation (AF) is the most common arrhythmia seen in clinical practice and is associated with increased risk of stroke, heart failure and death.(1) However, currently available treatments for AF are less than satisfactory. Many drugs have been tried with very limited success.(2) On the other hand, the demonstration of AF triggers in the atrial sleeves of the pulmonary veins (PVs)(3) has led to a significant improvement in therapy. Today PV isolation by means of radiofrequency (RF) ablation is a gold standard treatment for paroxysmal AF.(4) However, the success rate of RF ablation in the more prevalent and highly heterogeneous persistent and long-term persistent AF populations has been disappointing.(5) The reasons are probably multifactorial, but undoubtedly incomplete understanding of the mechanism(s) underlying this complex arrhythmia has contributed substantially to such a poor outcome...

Author-supplied keywords

  • Ablation
  • Arrhythmia (mechanisms)
  • Atrial fibrillation
  • Electrophysiology mapping
  • Imaging

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  • Felipe Atienza

  • Raphael P. Martins

  • José Jalife

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