Transposition of the great arteries: factors influencing prenatal diagnosis

  • Bertagna F
  • Rakza T
  • Vaksmann G
 et al. 
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OBJECTIVE: To highlight the factors that may affect prenatal diagnosis of TGA in order to improve it. METHODS: This is a retrospective study performed between 2004 and 2009 in the maternity units from North of France. We identified a total of 68 cases of TGA (isolated or associated with only ventricular septal defect or coarctation of aorta), of which 32 (47.1%) had prenatal diagnosis (PND+) and 36 did not (PND-). Maternal characteristics and ultrasound factors were studied in relation to prenatal diagnosis. RESULTS: Maternal weight and BMI were significantly higher in the PND- group (70.4 kg and 26.5 kg/m2 vs. 63.6 kg and 23.6 kg/m2 respectively). Maternal obesity (BMI > 30) was significantly more frequent in the PND- group (27.8% vs 12.5%). More than a quarter of TGA (28.1%) were diagnosed during the third trimester. CONCLUSION: Obesity is the main cause of missed prenatal diagnosis of TGA. Obese patients with suboptimal prenatal scans may benefit from reassessment of fetal cardiac anatomy and/or from referral for fetal echocardiography. This article is protected by copyright. All rights reserved.

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  • F Bertagna

  • T Rakza

  • G Vaksmann

  • N Ramdane-Sebbane

  • L Devisme

  • L Storme

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