Does treatment affect the levels of serum Interleukin-6, Interleukin-8 and procalcitonin in diabetic foot infection? A pilot study

  • Altay F
  • Şencan I
  • Şentürk G
 et al. 
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Aims: To investigate about serum PCT, IL-6 and IL-8 levels and how they are affected by the treatment in diabetic foot patients. Methods: Fifty patients' blood samples were taken to study ESR and CRP, IL-6, IL-8 and PCT before and at the 14th day of the treatment. Results: The pretreatment results of the 50 patients showed positive correlations between PCT and either ESH (r = 0.49, p < 0.001), or CRP (r = 0.56, p < 0.001). Similarly, there was a positive correlation between IL-6 and ESH (r = 0.46, p = 0.001), just like as it was between IL-6 and CRP (r = 0.54, p < 0.001). At the 14th day, the levels of ESR (70 ± 30.2 and 58.4 ± 26.2, p = 0.02), CRP (63.8 ± 73.1 and 18.1 ± 19.7, p < 0.001) and PCT (0.6 ± 2.1 and 0.05 ± 0.02, p = 0.007) were significantly decreased while IL-6 was decreased at a close range to statistical significancy at healing patients (97.5 ± 147.2 and 47.1 ± 77.6; p = 0.05), but they did not at nonhealing patients. IL-8 levels were not changed anyhow. Conclusions: PCT was significantly decreased such as ESR and CRP were in the early phase of healing; IL-6 and IL-8 levels were also decreased by the treatment, but not statistically significantly. IL-6 and PCT were affected in correlation with the other inflammatory parameters in the beginning, but IL-8 was not. PCT and IL-6 may be useful like CRP and ESR in the diagnosis and follow up of diabetic foot infection, but IL-8 is not. Further investigation is needed. © 2012 Elsevier Inc. All rights reserved.

Author-supplied keywords

  • C reactive protein
  • abscess
  • adult
  • aged
  • albumin
  • albumin blood level
  • amputation
  • antibiotic agent
  • antibiotic therapy
  • artery occlusion
  • article
  • clinical article
  • debridement
  • diabetic foot
  • disease duration
  • erythrocyte sedimentation rate
  • female
  • hemoglobin A1c
  • hemoglobin blood level
  • hormone blood level
  • human
  • human tissue
  • interleukin 6
  • interleukin 8
  • male
  • osteomyelitis
  • pilot study
  • priority journal
  • procalcitonin
  • protein blood level
  • treatment refusal

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  • F A Altay

  • I Şencan

  • G Ç Şentürk

  • M Altay

  • S Güvenman

  • S Ünverdi

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