Skip to content
Journal article

Treatment of Langerhans cell histiocytosis with pamidronate

Farran R, Zaretski E, Egeler R...(+3 more)

Journal of pediatric hematology/oncology, vol. 23, issue 1 (2001) p. 54

  • 4


    Mendeley users who have this article in their library.
  • 45


    Citations of this article.
  • N/A


    ScienceDirect users who have downloaded this article.
Sign in to save reference


A 14-year-old boy with longstanding multisystem Langerhans cell histiocytosis (LCH) had multifocal bone pain unresponsive to chemotherapy, corticosteroids, anti-inflammatories, and narcotic analgesics. He responded to two cycles of intravenous pamidronate, each 90 mg per day on three consecutive days. Two subsequent episodes of deterioration also responded to treatment. The pathophysiology of his bone pain and the likely mechanisms of biphosphonate action are discussed, with emphasis on the molecular and cellular basis of LCH.

Author-supplied keywords

  • analgesics
  • angerhans cell histiocytosis
  • biphosphonates
  • cells in conjunc-
  • is a monoclonal pro-
  • langerhans cell histiocytosis
  • lch
  • liferation of activated langerhans-like
  • osteolytic lesions
  • pain

Find this document

Get full text

Cite this document

Choose a citation style from the tabs below