Journal article

Treatment of Langerhans cell histiocytosis with pamidronate

Farran R, Zaretski E, Egeler R ...see all

Journal of pediatric hematology/oncology, vol. 23, issue 1 (2001) p. 54

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A 14-year-old boy with longstanding multisystem Langerhans cell histiocytosis (LCH) had multifocal bone pain unresponsive to chemotherapy, corticosteroids, anti-inflammatories, and narcotic analgesics. He responded to two cycles of intravenous pamidronate, each 90 mg per day on three consecutive days. Two subsequent episodes of deterioration also responded to treatment. The pathophysiology of his bone pain and the likely mechanisms of biphosphonate action are discussed, with emphasis on the molecular and cellular basis of LCH.

Author-supplied keywords

  • analgesics
  • angerhans cell histiocytosis
  • biphosphonates
  • cells in conjunc-
  • is a monoclonal pro-
  • langerhans cell histiocytosis
  • lch
  • liferation of activated langerhans-like
  • osteolytic lesions
  • pain

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  • R.P. Farran

  • Eldon Zaretski

  • R.M. Egeler

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