THE growth of solid neoplasms is always accompanied by neovascularization. This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in fresh wounds or in inflammation.1 Many workers have described the association between growing solid malignant tumors and new vessel growth.2 3 4 5 6 However, it has not been appreciated until the past few years that the population of tumor cells and the population of capillary endothelial cells within a neoplasm may constitute a highly integrated ecosystem. In this ecosystem the mitotic index of the two cell populations may depend upon each other. Tumor cells . . .
CITATION STYLE
Sherwood, L. M., Parris, E. E., & Folkman, J. (1971). Tumor Angiogenesis: Therapeutic Implications. New England Journal of Medicine, 285(21), 1182–1186. https://doi.org/10.1056/nejm197111182852108
Mendeley helps you to discover research relevant for your work.