Tumor cell recognition by γδ T lymphocytes: T-cell receptor vs. NK-cell receptors

  • Correia D
  • Lopes A
  • Silva-Santos B
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Abstract

The dissection of the molecular mechanisms underlying tumor-cell recognition by γδ T-cells is crucial to improve their performance in cancer immunotherapy. Here, we discuss the controversy around the relative contributions of the γδ T-cell receptor (TCR) and natural killer receptors (NKRs) to tumor-cell targeting by γδ T cells.

Author-supplied keywords

  • NK cell
  • NK receptor
  • NKG2D
  • T-cell receptor
  • γδ T cell

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Authors

  • Daniel V. Correia

  • António Lopes

  • Bruno Silva-Santos

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