TUMOR NECROSIS FACTOR alpha/CACHECTIN IS A GROWTH FACTOR FOR THYMOCYTES. SYNERGISTIC INTERACTION WITH OTHER CYTOKINE

  • Ranges G
  • Zlotnik A
  • Espevik T
 et al. 
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Abstract

Recombinant murine (rm) TNF-alpha but not recombinant human (rh) TNF-alpha induces the proliferation of murine thymocytes in the presence of a comitogenic stimulus. This effect does not appear to be due to the production of significant levels of IL-1, IL-2, or IL-4. although not directly mitogenic (i.e., in the absence of PHA-P) for thymocytes, rmTNF-alpha amplifies the direct mitogenic signals from hIL-1 and rhIL-2 but not rmIL-4. In the presence of PHA-P, thymocytes stimulated with hIL-1, rhIL-2, and rmIL-4 produced significant amounts of TNF-alpha. Although rhTNF-alpha does not induce a proliferative response, it will competitively inhibit the proliferative response of thymocytes to rmTNF-alpha. These data suggest a critical role for TNF-alpha in the intrathymic proliferation of developing T cells.

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  • PMID: 3282023

Authors

  • Gerald E Ranges

  • Albert Zlotnik

  • Terje Espevik

  • Charles A Dinarello

  • Anthony Cerami

  • Michael A Palladino

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