Tumorigenesis: Twist1 links EMT to self-renewal

  • Martin A
  • Cano A
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The epithelial-mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with the finding that Bmi1, a polycomb protein that promotes self-renewal of certain stem-cell populations, is a direct transcriptional target of the EMT inducer, Twist1.

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  • Alberto Martin

  • Amparo Cano

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