Tutorial in biostatistics: The self-controlled case series method

  • Whitaker H
  • Farrington C
  • Spiessens B
 et al. 
  • 253

    Readers

    Mendeley users who have this article in their library.
  • 295

    Citations

    Citations of this article.

Abstract

The self-controlled case series method was developed to investigate associations between acute outcomes and transient exposures, using only data on cases, that is, on individuals who have experienced the outcome of interest. Inference is within individuals, and hence fixed covariates effects are implicitly controlled for within a proportional incidence framework. We describe the origins, assumptions, limitations, and uses of the method. The rationale for the model and the derivation of the likelihood are explained in detail using a worked example on vaccine safety. Code for fitting the model in the statistical package STATA is described. Two further vaccine safety data sets are used to illustrate a range of modelling issues and extensions of the basic model. Some brief pointers on the design of case series studies are provided. The data sets, STATA code, and further implementation details in SAS, GENSTAT and GLIM are available from an associated website.

Author-supplied keywords

  • Case series
  • Conditional likehood
  • Control
  • Epidemiology
  • Modelling
  • Proportional incidence

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Heather J. Whitaker

  • C. Paddy Farrington

  • Bart Spiessens

  • Patrick Musonda

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free