A tutorial on statistical methods for population association studies.

  • Balding D
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Abstract

Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview of statistical approaches to population association studies, including preliminary analyses (Hardy-Weinberg equilibrium testing, inference of phase and missing data, and SNP tagging), and single-SNP and multipoint tests for association. My goal is to outline the key methods with a brief discussion of problems (population structure and multiple testing), avenues for solutions and some ongoing developments.

Author-supplied keywords

  • Genetics, Medical
  • Genetics, Population
  • Genome, Human
  • Genotype
  • Haplotypes
  • Humans
  • Polymorphism, Single Nucleotide
  • Statistics as Topic
  • genetics
  • methods

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Authors

  • David J D J Balding

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