Two genes encode distinct glutamate decarboxylases

  • Erlander M
  • Tillakaratne N
  • Feldblum S
 et al. 
  • 154

    Readers

    Mendeley users who have this article in their library.
  • 913

    Citations

    Citations of this article.

Abstract

γ-Aminobutyric acid (GABA) is the most widely distributed known inhibitory neurotransmitter in the vertebrate brain. GABA also serves regulatory and trophic roles in several other organs, including the pancreas. The brain contains two forms of the GABA synthetic enzyme glutamate decarboxylase (GAD), which differ in molecular size, amino acid sequence, antigenicity, cellular and subcellular location, and interaction with the GAD co-factor pyridoxal phosphate. These forms, GAD65and GAD67, derive from two genes. The distinctive properties of the two GADS provide a substrate for understanding not only the multiple roles of GABA in the nervous system, but also the autoimmune response to GAD in insulin-dependent diabetes mellitus. © 1991.

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Mark G. Erlander

  • Niranjala J.K. Tillakaratne

  • Sophie Feldblum

  • Neela Patel

  • Allan J. Tobin

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free