Two new stilbene dimer glucosides from grape (Vitis vinifera) cell cultures

  • Waffo-Teguo P
  • Lee D
  • Cuendet M
 et al. 
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Abstract

Two new stilbene dimer glucosides, resveratrol (E)-dehydrodimer 11-O-beta-D-glucopyranoside (1) and resveratrol (E)-dehydrodimer 11'-O-beta-D-glucopyranoside (2), were isolated together with the known resveratrol (E)-dehydrodimer (3) and pallidol (4) from Vitis vinifera cell cultures. The structures and stereochemistry of the new compounds were determined on the basis of spectroscopic data analysis. Compounds 1 and 2 are dimers that belong to a new type of oligostilbene formed from a resveratrol unit and a resveratrol glucoside unit. Compounds 1 and 3 exhibited nonspecific inhibitory activity against cyclooxygenase-1 and -2, with IC(50) values in the range of 5 microM, whereas compound 4 was approximately 10-fold less active.

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Authors

  • Pierre Waffo-Teguo

  • Dongho Lee

  • Muriel Cuendet

  • Jean Michel M??rillon

  • John M. Pezzuto

  • A. Douglas Kinghorn

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