Two Types of Intrinsic Oscillations in Neurons of the Lateral and Basolateral Nuclei of the Amygdala

  • Pape H
  • Paré D
  • Driesang R
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Pape, Hans-Christian, Denis Paré, and Robert B. Driesang. turn, can be assumed to promote population activity at this particu-lar frequency, which ranges well within that of the limbic theta Two types of intrinsic oscillations in neurons of the lateral and (U) rhythm and the delta (d) waves in the electroencephalogram basolateral nuclei of the amygdala. J. Neurophysiol. 79: 205–216, during slow-wave sleep. 1998. Intracellular recordings in the guinea pig and cat basolateral amygdaloid (BL) complex maintained as slices in vitro revealed that a subpopulation of neurons (79%) in the lateral (AL) and I N T R O D U C T I O N basolateral (ABl) nuclei generated two types of slow oscillations of the membrane potential upon steady depolarization from resting Recent anatomic, physiological, and behavioral findings potential. The cells were of a stellate or pyramidal-like shape and have lead to significant insights into the functions of the possessed spiny dendrites and an axon leaving the local synaptic amygdala in emotional and social behavior (Aggleton 1992; environment, and thus presumably represented projection neurons. Davis 1992; LeDoux 1991). In addition, there is growing Similar oscillatory activity was observed in projection neurons of evidence that dysfunctions of the amygdala contribute to the cat AL nucleus recorded in vivo. Oscillatory activity with a certain clinical conditions, including anxiety disorders, de-low threshold of activation (low-threshold oscillation, LTO) ap-peared as rhythmic deflections (amplitudes, 2–6 mV) of the mem-mentia, and schizophrenia (Aggleton 1993). In view of the brane potential positive to 060 mV. Fast Fourier transformation important role of the amygdala, a more detailed understand-(FFT) demonstrated a range of frequencies of LTOs between 0.5 ing of the underlying cellular mechanisms is required, partic-and 9 Hz, with ú80% occurring at 1–3.5 Hz and an average at ularly of the intrinsic membrane properties of the neurons. 2.3 { 1.1 Hz. LTOs were more regular after pharmacological In fact, neurons in the mammalian brain have been found blockade of synaptic transmission and were blocked by tetrodo-to possess a large variety of distinctive membrane conduc-toxin (TTX). Blockade of LTOs and Na

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  • Hans-Christian Pape

  • Denis Paré

  • Robert B Driesang

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