Ultrastructural glomerular changes in experimental infection with the classical swine fever virus.

  • Calder�n N
  • Paasch L
  • Fortoul T
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Ultrastructural studies of glomerular changes were performed on 16
pigs experimentally infected with a highly virulent strain of the
classical swine fever virus. Our observations revealed the thickening
of glomerular basement membranes and swelling of endothelial cells
and cytoplasmic vacuolization within podocytes containing abundant
viral particles. An early viral infection of podocytes was suggested
as the cause of selective swelling of the foot processes of these
cells with the consequent obliteration of the glomerular urinary
spaces. To our knowledge this is the first report of ultrastructural
evidence of classical swine fever virions infecting glomerular podocytes.

Author-supplied keywords

  • Animals; Classical Swine Fever and pathology; Clas

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  • N L Calder�n

  • L H Paasch

  • T I Fortoul

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