'Unfolding' pathways in neurodegenerative disease

  • Forman M
  • Lee V
  • Trojanowski J
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Abstract

The endoplasmic reticulum responds to stress by initiating a cascade of events known as the 'unfolded-protein response' (UPR). The accumulation of misfolded proteins in the leukodystrophy Pelizaeus-Merzbacher disease activates this stress response, resulting in apoptosis of oligodendrocytes. Although it remains uncertain whether the UPR plays a mechanistic role in prototypical neurodegenerative disorders such as Alzheimer's disease, this is plausible because misfolded proteins are directly implicated in the pathogenesis of these disorders.

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Authors

  • Mark S. Forman

  • Virginia M.Y. Lee

  • John Q. Trojanowski

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