Untangling the cortex: Advances in understanding specification and differentiation of corticospinal motor neurons

  • Shoemaker L
  • Arlotta P
  • 60

    Readers

    Mendeley users who have this article in their library.
  • 15

    Citations

    Citations of this article.

Abstract

The mature cerebral cortex contains a staggering variety of projection neuron subtypes, and a number of complementary studies have recently begun to define their identity and embryonic origin. Among the different types of cortical projection neurons, subcerebral projection neurons, including corticospinal motor neurons (CSMN), have been extensively studied and some of the molecular controls over their differentiation have been elucidated. Here, we first provide an overview of the approaches used to purify and molecularly profile neuronal populations of the neocortex and, more broadly, of the central nervous system (CNS). Next, we specifically review recent progress in understanding the genes that define and control development of the CSMN population. Finally, we briefly discuss the relevance of this work to current questions regarding the mechanisms of the establishment of projection neuron subtype identity in the neocortex and its implications to direct the differentiation of CSMN for therapeutic benefit.

Author-supplied keywords

  • Bhlhb5
  • Clim1
  • Corticospinal motor neurons (CSMN)
  • Crim1
  • Ctip2
  • Diap3
  • FACS
  • Fezf2
  • Mu-Crystallin
  • Satb2
  • Sox5
  • Subcerebral projection neurons

Get free article suggestions today

Mendeley saves you time finding and organizing research

Sign up here
Already have an account ?Sign in

Find this document

Authors

  • Lorelei D. Shoemaker

  • Paola Arlotta

Cite this document

Choose a citation style from the tabs below

Save time finding and organizing research with Mendeley

Sign up for free